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Hépatite fulminante chez deux enfants traités par la salazopyrine pour une maladie de CrohnSalazopyrin-induced fulminant hepatitis in two children treated for. Request PDF on ResearchGate | Hépatite fulminante à virus Epstein-Barr: évolution favorable après transplantation hépatique | Viral hepatitis are the leading. Request PDF on ResearchGate | On Oct 1, , E. Mériglier and others published Hépatite fulminante fatale à virus de la varicelle-zona chez une patiente.

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Lobular inflammation with lymphocytes, plasmocytes, some neutrophils and numerous histiocytes were also detected Figs 12 e 3.

The authors declare that no patient data appear in this article. Although not reaching statistical significance, ballooning, pseudo-rosette formation, steatosis and plasma cells were more prevalent in HEV.

Extracorporeal albumin dialysis was initiated, but clinical deterioration occurred hepattite 48 h, so she underwent OLT at day 4 post-admission. Viruses especially hepatitis viruses A and Bdrugs, and toxic agents are the most common causes of fulminant hepatitis, with the proportions varying between countries.

She was icteric with grade III encephalopathy and hypothermia. Khuroo MS, Kamill S.

Immunocompromised individuals should always be tested for HEV RNA, if there is suspicion that they are infected, because seroconversion can be delayed in these patients. Transmission routes and risk factors for autochtonous hepatitis E virus infection in Europe: Serologic assays specific to immunoglobulin M antibodies against hepatitis E virus: These patients can be treated only in specialized centers with access to liver transplantation and to different modern means of liver resuscitation hypothermia, artificial liver support, albumin dialysis, monitoring intracranial pressure and cerebral perfusion, etc.


The authors declare that they have followed the protocols of their work center on the publication of patient data and that all the patients included in the study received sufficient information and gave their written informed consent to participate in the study. Indian J Med Res.


Ribavirin treatment for chronic hepatitis E: Severe hepatitis E infection during pregnancy. There is a clear shift in the T-helper type 1 Th1: She returned to Portugal during the third trimester of her pregnancy, 3 weeks before admission in our Hospital. The latter leads to spotty or confluent necrosis, portal and lobular inflammation, ballooning degeneration of hepatocytes, intracytoplasmic and intracanalicular cholestasis and hepatocyte pseudo-rosette formation, in accordance with the features of our case.

Aggarwall R, Jameel S. Il existe aussi des causes plus rares: Heaptite to the full text of this article requires a subscription. Prognosis is essentially determined by neurological status, but is also affected very rapidly by damage to other organs. Pathogenesis fulminanre treatment of hepatitis E virus infection.

Hepatitis E is an inflammatory liver disease caused by hepatitis E virus HEV infection, which is a single-stranded, non-enveloped RNA virus and the only virus within the genus Hepevirus and the family Hepeviridae. The histological analysis revealed extensive areas of confluent panlobular, non-zonal necrosis, with porto-portal, porto-central and centro-central bridges. Bilirubin was significantly elevated In symptomatic cases, the incubation period ranges from 2 to 8 weeks, with a mean of 40 days.

Aetiology, clinical course and outcome of fuominante acute viral hepatitis in pregnancy. However, more severe forms of acute liver disease can occur in pregnant women or patients with underlying chronic liver diseases, sometimes progressing to fulminant hepatic failure. Does hepatitis E viral load and genotypes influence the final outcome of acute liver failure during pregnancy?

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Quadro de Resumo

You can move this window by clicking on the headline. The pseudorosettes a striking feature of our case are uncommon in the western cases and frequent in the cases in endemic areas. Furthermore, vertically transmitted HEV infection through cord blood is known to cause acute hepatitis in newborn babies. Her background was unremarkable, she was married and mother of a 2-year-old healthy child, with a regular pregnancy and an eutocic delivery and a history of 2 previous spontaneous abortions.

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Hepatitis E virus infection and fulminante hepatic failure during pregnancy.

Hepatites – Quadro de resumo

Severe forms of HEV are known to be more pronounced in pregnant women. Liver transplant is considered an option, but it is unknown whether its outcomes in this setting are different from other causes of acute liver failure. Histological and immunohistochemical features in fatal acute fulminant hepatitis E. As the majority of cases are self-limited, liver biopsy is not usually performed, so the histology data about HEV acute hepatitis are scarce.

She had a normal platelet count. She denied current medication and toxic or alcohol consumption.

The genotype of this patient is not available yet, and hepatife though there is some speculation regarding the influence of the genotype on clinical features in this setting, that remains to be proven. Liver histology in patients with sporadic acute hepatitis E: Conflicts of interest The authors have no conflicts of interest to declare. Indian J Pathol Microbiol. The histology of acute autochthonous hepatitis E virus infection. PCR for Hepatitis E RNA was strongly positive, so she was diagnosed with acute hepatic failure caused by acute hepatitis E, with hepatic encephalopathy.

Received 17 October ; accepted 29 April There is a complex hepatkte among viral, host, immunological and hormonal factors, producing a paradigma of severe liver damage in pregnancy.