Updated : Oct 25, 2019 in Art


This is an important contribution, adding to the understanding of bone remodeling, which is not just relevant to arthritis but also to degenerative bone changes. Degenerative and inflammatory joint diseases lead to a destruction of the joint architecture. Whereas degenerative osteoarthritis results in the formation of new . Figure 3 New bone formation next to inflamed joints is increased upon blockade of DKK (a) Microphotographs of toluidine blue–stained joint sections of, ”from.

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Dickkopf-1 is a master regulator of joint remodeling

After 24 h of incubation it was treated with methylthiazol tetrazolium solution Sigma and following a 4 h incubation, dimethyl sulphoxide was added and read at nm in a spectrophotometer. Maini Journal of autoimmunity The mastdr basis of these different patterns of joint disease is unknown.

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Dickkopf-1 is a master regulator of joint remodeling.

It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide. Showing of extracted citations. Melissa M MatzelleMaxime A. Conflicting results regarding the role of DKK-1 in cell migration have been described in different cell types, including hepatocellular carcinoma cells [ 13 ], intestinal epithelial cells [ 14 ], HEK cells [ 15 ] and thyroid cancer cells [ 16 ].


Whereas degenerative osteoarthritis results in the formation of new bone, rheumatoid arthritis leads to bone resorption.

Citations Publications citing this paper.

Dickkopf-1 is a master regulator of joint remodeling.

Close mobile search navigation Article navigation. WalshTania N. Dkk-1 dickkopff-1 intestinal epithelial cell migration by attenuating directional polarization of leading edge cells. I agree to the terms and conditions. Sign In or Create an Account.

Immunoblotting was performed as described previously [ 27 ].

Rheumatoid arthritis progression mediated by activated synovial fibroblasts. Gravallese Immunological reviews Bone Loss in Rheumatoid Arthritis: Register for day free trial Registration is free and only takes a moment, or subscribe for unlimited access.

Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis. Cell migration was shown to be increased in both human primary hepatocellular cells and immortalized HEK cells overexpressing DKK-1 [ 1314 ], whereas the opposite effect was observed in studies with thyroid cancer and intestinal epithelial cells [ 1416 ]. Maini Journal of autoimmunity IL induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy.


The binding of integrins to ECM proteins activates diverse non-receptor protein tyrosine kinase signalling pathways, including the FAK, c-Src and Syk pathways. Ix Journal of bone and mineral research: Methotrexate achieves major cDAPSA response, and improvement in dactylitis and functional status in psoriatic arthritis.

Williams Journal of bone and mineral research: Methylthiazol tetrazolium assay was performed on cell for dosage fixation of all drugs. Integrins, which comprise a family of heterodimeric transmembrane proteins that link to ECM proteins such as fibronectin, vitronectin and laminin, regulate both cell migration and tissue remodelling [ 30 ].

This up-regulation was confirmed on the protein level by divkkopf-1 microscopy supplementary Fig. From This Paper Figures, tables, and topics from this paper.

Wnt signaling in bone formation and its therapeutic potential for bone diseases. WalshTania N. Whereas degenerative osteoarthritis results in the formation of new bone, rheumatoid arthritis leads to bone resorption. References Publications referenced by this paper.