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We report a case of primary cutaneous infection by the emerging fungus Aspergillus ustus in an immunosuppressed patient after a domestic accident. Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported. We report the first outbreak of invasive infection caused by A . Med Mycol. Jun;45(4) Clustering of invasive Aspergillus ustus eye infections in a tertiary care hospital: a molecular epidemiologic study of an.

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Aspergillus ustus | Aspergillus & Aspergillosis Website

Charts were reviewed for clinical data demographics, underlying disease, transplantation characteristics, antifungal therapies, radiographic and laboratory studies, and outcome. Please review our privacy policy. Aspergillus Fungi described in Pavie J, Lacroix C, Hermose DG Breakthrough disseminated Aspergillus ustus infection in allogeneic hematopoietic stem cell transplant recipients receiving voriconazole and caspofungin prophylaxis.

Estimating that patients were admitted for HSCT during the at-risk period, the highest overall attack rate was 1. The pH of the medium is not modified by the species final pH 6. Open in a separate window. This article has been cited by other articles in PMC.

Specifically, genomic rearrangement with recombination, which has been postulated to occur in several species of Aspergillusmay increase the variation observed between related strains Curr Infect Dis Rep. The latter may occur in A.

On Czapek growth medium pH 5. Molecular typing of Aspergillus ustus isolates by using random amplification of polymorphic DNA.

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Patient 3 was in the outpatient clinic at the time of diagnosis and is, therefore, not marked on this inpatient spot map. Although the clinical isolates appear different from the ATCC strain, the genetic similarity of case strains may represent a strain common to our local environment. These outbreaks of A. Journal of Clinical Microbiology. Bilateral pulmonary consolidation, skin lesion. The hospital is a large tertiary care facility that houses patients with Aspegillus on the top 2 floors the northeast wings of the seventh and eighth floors.

Primary cutaneous infection by Aspergillus ustus in a year-old liver transplant recipient. Patients were in and out of the hospital after transplantation, so infection could have been acquired in the environment.

Aspergillus ustus – Wikipedia

CMV, parainfluenza pneumonia; BK virus hemorrhagic cystitis. Fever, chest pain, nodular pulmonary opacity. Antifungal drug susceptibility testing of clinical isolates demonstrated relatively high MICs to all antifungal drugs tested Table 2. Antifungal drug aspergillux testing of A. Also, several patients who were not found to have A.

The strain from the pediatric patient differed from the ophthalmic isolates in five electrophoretic loci. Bartizal C, Odds FC Influences of methodological variables on susceptibility testing of caspofungin against Candida species and Aspergillus fumigatus. On CYA growth medium pH 5. This study also emphasizes the importance of establishing microbial diagnoses to the species level; information obtained is important for infection control and, asprgillus, to guide antifungal therapies.

From Wikipedia, the free encyclopedia.

Aspergillus ustus

Aspergillus ustus has been found on the surfaces of walls of caves and in indoor air of buildings [8] including hospitals, [3] [9] soils and bat dung. Aspergillus ustus Aspergillus ustus group colony on Modified Leonian’s agar Scientific classification Kingdom: Common source acquisition may not be precluded by case isolate separation in time as Aspergillus conidia are resistant to harsh conditions, surviving in the environment aspergilpus many years in dormant phase In three of the cases, the patients required enucleation following cataract surgery, while the fourth involved a fatal infection in a pediatric patient hospitalized for osteopetrosis.


Three isolates from patient 5 were genetically most similar to aspergillis isolate from patient 2. Aspergillus ustus group colony on Modified Leonian’s agar. Articles with ‘species’ microformats.

All previously reported cases occurred sporadically in diverse medical centers Ustux A1. RAPD and phylogenetic analysis showed genetic similarity between isolates from different patients. Sharp, demarcated white areas over dorsal hands and arms.

Azzola P Jr, Habicht JM Use of lung resection and voriconazole for successful treatment of invasive pulmonary Aspergillus ustus infection.

Recognition of invasive infections that occurred in 2 clusters of hematopoietic stem cell transplant HSCT recipients in our institution prompted us to perform aspergiluls more thorough clinical investigation and environmental sampling to identify potential sources of acquisition. Thus, the source of A.