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Macular amyloidosis is a pruritic eruption that is variable in severity and consists of small, dusky-brown or grayish pigmented macules. Macular amyloidosis (MA) is the most subtle form of cutaneous amyloidosis, characterized by brownish macules in a rippled pattern, distributed predominantly. CASE REPORT. An unusual presentation of macular amyloidosis. Bárbara Lima Araújo MeloI; Igor Santos CostaII; Clara de Assis Martins GoesIII; Celina Aguiar.

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If the condition affects nerves that control blood pressure, you may experience dizziness or near fainting when standing too quickly.

Primary cutaneous amyloidosis – Wikipedia

Advertising revenue supports our not-for-profit mission. For want of the requisite information on the natural course and definitive etiology the disease, MA remains an enigma and a source of concern for the suffering patients and physicians.

Histochemistry and electron microscopy. Overview Amyloidosis am-uh-loi-DO-sis is a rare disease that occurs when a substance called amyloid maculae up in your organs. Characteristic findings on physical examination Macular amyloidosis typically presents as gray-brown pruritic macules, which zmiloidosis coelesce into patches with a rippled pattern involving the upper back Figure 1 and less often the arms, chest and thighs.

Mayo Clinic Marketplace Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. The three main forms of primary localized cutaneous amyloidosis are lichen amyloidosis, macular amyloidosis, and nodular amyloidosis. Hashimoto K, Kobayashi H. Amyloidogenesis in organ-limited cutaneous amyloidosis: MA is a primary cutaneous form and is characterized by hyperpigmented macules on the upper back, particularly between the shoulder blades.

In the patient studied here mcaular failed to reveal any abnormal results. Specialised Social Services Eurordis directory. There is no convincing explanation for the origin of the amyloid protein in the skin. Lichen amyloidosus without itching indicates that it is macula secondary to chronic scratching. The potential complications of amyloidosis depend on which organs the amyloid deposits affect.


Another report involving a patient who was treated with NB UVB three times per week showed marked improvement after 5 months of treatment. Intermittent use of topical dimethyl sulfoxide in macular and papular amyloidosis.

Primary cutaneous amyloidosis

Enlarged tongue An enlarged tongue macroglossia can be a sign of amyloidosis. Amyloidosis is an extra-cellular deposition of the fibrous protein either involving multiple organ systems systemic amyloidosis or maculat to a single-tissue site localized amyloidosis.

In mild cases, topical corticosteroids have been beneficial. Failure of etretinate RO in lichen amyloidosus. There were no systemic findings. A year-old, dark-skinned housewife was followed amiloiosis after presenting with a one-year complaint of dark, non-itching lesions on her arms, neck, lower back and legs.

Clin Endocrinol Oxf ; Patient education is important in breaking the itch-scratch-itch cycle. For want of the requisite information on the natural course and definitive etiology, the disease MA remains an enigma and a source of concern for the suffering patients.

After systemic involvement had been excluded, topical photoprotection was started and the patient was followed up. An assessment of prevalence, sex, and age. However, as treatment follow-up lasted only two months, possible side effects such as residual hypopigmentation were not identified, particularly in patients with phototypes V or VI, for whom six months follow-up after the multiple laser sessions would be required. When signs and symptoms are evident, they depend on which of your organs are affected.

It is also important to know that both lichen amyloidosis and macular amyloidosis share the ability to stain positive for antikeratin antibodies.


Only comments written in Jacular can be processed. Approved by the Advisory Board and accepted for publication on J Eur Acad Dermatol Venereol. J Eur Acad Dermatol Venereol.

Occasionally, MA and lichen amyloidosis may coexist in the same patient, a condition known as biphasic amyloidosis. No amyloid was detected around blood vessels or other cutaneous appendages. Amyloidosis can seriously damage your:. Mechanical trauma such maculaar that induced by nylon fibers and bristles has been considered in the etiology of MA and has been reported under various names, such as friction amyloidosis, towel melanosis and nylon clothes friction dermatitis.

Apoptosis in primary cutaneous amyloidosis. In cases of extensive or nodular cutaneous lesions it is important to amiloidoiss out a systemic assessment. Bony prominences such as clavicular and scapular regions were involved in three patients each, with rare sites like the buttocks being involved in mavular patient. Mc Graw Hill Inc; It has been suggested that female preponderance maybe due to medical attention sought earlier by women for the cosmetically disturbing pigmentation.

Macular Amyloidosis (Friction Amhyloidosis)

How to cite this article. In our study comprising 50 patients from Northern India, we studied the possible etiological and risk factors of MA. We did not observe such a pattern in our study. Amyloidosis am-uh-loi-DO-sis is a rare disease that occurs when a substance called amyloid builds up in your organs. Check this box if you wish to receive a copy of your message.

Orphanet: Amiloidosis macular

Congo Red staining left and Thioflavin-T staining with fluorescent microscopy right. Other search option s Alphabetical list. Primary localized cutaneous amyloidosis: